A COMPUTATIONAL APPROACH TO MODELING AN ANTAGONISTIC ANGIOGENIC VEGFR1-IL2 FUSION PROTEIN FOR CANCER THERAPY


CAR T-cell immunotherapy of MET-expressing malignant mesothelioma

Mesothelioma is an incurable cancer for which effective therapies are required.Aberrant MET expression is prevalent in mesothelioma, although targeting using small molecule-based therapeutics has proven disappointing.Chimeric antigen receptors (CARs) couple the HLA-independent binding of a cell surface target to the delivery of a tailored T-cell ac

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Akkermansia muciniphila - friend or foe in colorectal cancer?

Akkermansia muciniphila is a gram-negative anaerobic bacterium, which represents a part of the commensal human microbiota.Decline in the abundance of A.muciniphila among other microbial species in the gut correlates OBDII T-Harness with severe systemic diseases such as diabetes, obesity, intestinal inflammation and colorectal cancer.Due to its muci

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